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A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine.
Saadati, Fariba; Cammarone, Silvia; Ciufolini, Marco A.
Chemistry ; 28(48): e202200906, 2022 Aug 26.
Article in English | MEDLINE | ID: covidwho-2047510

ABSTRACT

This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.


Subject(s)
COVID-19 Vaccines , COVID-19 , Amination , Amino Alcohols , COVID-19/prevention & control , Decanoates , Humans , Lipids , Oxidation-Reduction , Vaccines, Synthetic , mRNA Vaccines
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